01 April 2004
Yogurt feeding inhibits promotion and progression of experimental colorectal cancer
Alejandra de Moreno de LeBlanc, Gabriela PerdigónMed Sci Monit 2004; 10(4): BR96-104 :: ID: 11626
Abstract
Background: In BALB/c mice, a yogurt diet given before and after the carcinogen 1, 2 dymethylhydrazine
(DMH) inhibited colon cancer. This paper studied at which stage of tumor development (initiation, promotion or progression) yogurt exerts its antitumor activity.
Material/Methods: Six experimental groups were used: 1) non-treatment control; 2) DMH control; 3) yogurt-
DMH-yogurt: yogurt administered before and after DMH. 4) yogurt-DMH: yogurt given only
10 days before DMH; 5) DMH-yogurt: yogurt given cyclically after DMH; and 6) yogurt control. The groups DMH-yogurt and yogurt-DMH were compared histologically and TNFα, INFγ, IL-10 and IL-4 cytokines, CD4[sup]+[/sup]/CD25[sup]+[/sup] T cells, and apoptotic cells were determined in large intestine biopsies. TNFα and INFγ were also determined in cells isolated from large
intestine nodules and from Peyer’s patches.
Results: The DMH-yogurt group did not develop tumor. The yogurt-DMH group showed only tumor
delay; TNFα, INFγ and IL-10 increasing in this group in all the periods assayed. These results agree with those already reported for DMH control and yogurt-DMH-yogurt. There was no correlation between the high levels of IL-10 and CD4[sup]+[/sup]/CD25+ T regulatory population. IL-4 and apoptotic cells increased in the yogurt-DMH group only in the first months. In the DMHyogurt group, cellular apoptosis increased during the whole treatment. Yogurt feeding
induced TNFα and INFγ increases in cells isolated from large intestine nodules. These cytokines also increased in cells from Peyer’s patches of the yogurt control group.
Conclusions: These results show that yogurt inhibited tumor progression and promotion by modulating the immune response and stimulating cellular apoptosis.
Keywords: 1,2-Dimethylhydrazine - toxicity, Antigens, CD4 - immunology, Apoptosis - physiology, Carcinogens - toxicity, Colorectal Neoplasms - chemically induced, Colorectal Neoplasms - diet therapy, Cytokines - metabolism, Intestines - immunology, Intestines - pathology, Peyer's Patches - immunology, Peyer's Patches - pathology, Receptors, Interleukin-2 - immunology, T-Lymphocytes - cytology, T-Lymphocytes - immunology, Yogurt - microbiology, 1,2-Dimethylhydrazine - toxicity, Antigens, CD4 - immunology, Apoptosis - physiology, Carcinogens - toxicity, Colorectal Neoplasms - diet therapy, Cytokines - metabolism, Intestines - pathology, Peyer's Patches - pathology, Receptors, Interleukin-2 - immunology, T-Lymphocytes - immunology, Yogurt - microbiology
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
06 Mar 2024 : Clinical Research
Prevalence and Variation of Medical Comorbidities in Oral Surgery Patients: A Retrospective Study at Jazan ...Med Sci Monit In Press; DOI: 10.12659/MSM.943884
08 Mar 2024 : Clinical Research
Evaluation of Foot Structure in Preschool Children Based on Body MassMed Sci Monit In Press; DOI: 10.12659/MSM.943765
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952