25 June 2003
Demonstration of monoclonality in coexisting GH-producing adenoma and neuronal tissue
Hidetoshi Ikeda, Wenbin Ma, Takashi YoshimotoMed Sci Monit 2003; 9(6): CS47-52 :: ID: 12838
Abstract
Background:Pituitary adenoma and neuronal components may coexist in the sellar region, but discussion of the histogenesis of the neuronal component has been mainly based on the morphological similarity with the adenomatous component using immunohistochemical and ultrastructural methods. Neuronal differentiation within pituitary adenoma may be a metaplastic process, but no clear supporting evidence has been obtained. To investigate the monoclonality or polyclonality of the mixed lesion by the X-chromosome inactivation method.Case Report:Tumor specimens from a 55-year-old acromegalic woman were subjected to histopathological study and clonal analysis. Histological examination found varying proportions of adenoma cells and neuronal component in the specimens. Light and electron microscopy revealed cells with transitional morphology between adenoma cells and neurons. However, the X-chromosome inactivation method demonstrated monoclonality of both adenoma and neuron-like cells.Conclusions:Clonal analysis of the mixed lesion demonstrated that all tumor cells originated from a single cell.
Keywords: Adenoma - genetics, Adenoma - pathology, Adenoma - secretion, Chromosomes, Human, X - genetics, Human Growth Hormone - secretion, Pituitary Neoplasms - genetics, Pituitary Neoplasms - pathology, Pituitary Neoplasms - secretion
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
18 Apr 2024 : Clinical Research
Comparative Analysis of Open and Closed Sphincterotomy for the Treatment of Chronic Anal Fissure: Safety an...Med Sci Monit In Press; DOI: 10.12659/MSM.944127
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952