01 September 2003
Serum levels of interleukin-12 (IL-12) and peripheral blood lymphocyte population counts in children with protein-calorie malnutrition
Krzysztof Marek, Andrzej Marek, Maria KorzonMed Sci Monit 2003; 9(4): 7-10 :: ID: 428621
Abstract
Background: Protein-calorie malnutrition (PCM)disturbs profoundly the functions of the immune system, especially the cellular type immune response.In order to find the immunological criterion of malnutrition severity and effectiveness of realimentation, the reported first phase of the study attempted to assess quantitatively the phenotypic characteristics of peripheral blood lymphocytes and to test the correlations between serum Il-12 levels and the counts of specific lymphocyte subpopulations in blood of children with PCM. Material/Methods: In 50 children with PCM, subjective and objective examinations were performed and somatic development assessed.All the children underwent routine blood count tests and determinations of CD19+(LB),CD3+(LT),CD4+(LTh), CD8+(LTc/s), CD3HLADR+(active LT)and NK cells (CD56)population counts performed using monoclonal antibodies and flow cytometry. Additionally, serum Il-12 levels were determined by ELISA.Results: Malabsorption syndrome was the most common cause of malnutrition in the examined children. Both body weight and body mass indices (BMI) of 49 children were below the 3 rd percentile and in 1 child –between the 3 rd and 10 th percentile. Although total blood lymphocyte counts were decreased in 19 children (38%)only, cytometry demonstrated reduced populations of LB in 56%, LT in 52%, LTCD8+in 56%, LTCD4+in 36%, LT HLADR+in 74%and NK cells in 62%of children.Serum IL-12 levels ranged from 8.78 pg/ml to 242.36 pg/ml (x –130.93 pg/ml)and demonstrated a statistically significant positive correlation with the number of LT and the counts of their specific subpopulations (r=0.41 –0.54, p
Keywords: protein-calorie malnutrition, children, lymphocyte subpopulations, IL--12
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
08 Mar 2024 : Clinical Research
Evaluation of Foot Structure in Preschool Children Based on Body MassMed Sci Monit In Press; DOI: 10.12659/MSM.943765
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952