01 November 2005
Antioxidant and hepatoprotective effects of Eucalyptus maculata.
Abdel-Fattah Mohamed, Abeer Gafar Ali Hasan, Mahmoud Ismail Hamamy, Essam Abdel-SattarMed Sci Monit 2005; 11(11): BR426-431 :: ID: 430302
Abstract
BACKGROUND: Since phenolic compounds have been reported as effective antioxidants, this study was designed to assess the hepatoprotective and antioxidant activities of the chloroformic extract of the resinous exudate and its phenolic constituents obtained from the stems of Eucalyptus maculata. MATERIAL/METHODS: The chloroformic extract and pure phenolic isolates were evaluated for their antioxidant and hepatoprotective properties in mice and rats based on biochemical changes in serum and tissues as well as pathological changes in the liver and spleen. RESULTS: Acetaminophen (ACP) at a dose of 1 g/kg body weight produced 100% mortality in mice, while pretreatment of animals with the chloroformic extract (125 and 250 mg/kg) protected against the moralities by 66%. Pretreatment of rats with either the chloroformic extract (250 mg/kg) or any of the pure isolates (20 mg/kg) significantly reduced the increase in serum level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) produced by ACP (640 mg/kg). Pretreatment of animals with the chloroformic extract or its isolates also protected against ascorbic acid depletion in serum and kidney tissues induced by oral administration of paraquat (PQ) without modifying the serum level of glutathione (GSH) and glycogen content in liver tissue. CONCLUSIONS: The phenolic content of the chloroformic extract and the pure isolates produced an antioxidant activity which may be due to the formation of stable phenoxyl radical in addition to its effect through vitamin C.
Keywords: Acetaminophen - toxicity, Antioxidants - pharmacology, Eucalyptus - chemistry, Liver - pathology, Mice, Inbred Strains, Oxidative Stress - drug effects, Paraquat - toxicity, Phenobarbital - antagonists & inhibitors, Phenols - pharmacology, Plant Extracts - pharmacology, Protective Agents - pharmacology, Rats, Inbred Strains, Sleep - drug effects
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952