Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

21 October 2002

Comparative analysis of lipid profiles assessed by ultracentrifugation in patients with various hyperlipoproteinaemia types in correlation with hepatic steatosis.

Tadeusz Tacikowski, Jan Dzieniszewski, Grazyna Nowicka, Janusz Ciok

Med Sci Monit 2002; 8(10): CR697-701 :: ID: 4868

Abstract

BACKGROUND: The purpose of our study was to compare lipid profile assessed by ultracentrifugation in various types of hyperlipoproteinemia (HLP) in correlation with obesity and hepatic steatosis diagnosed in the ultrasonic examination of the abdominal cavity. MATERIAL/METHODS: We studied 64 patients (38 women and 26 men with a mean age of 53.5 years) with various types of HLP, divided into two groups: 1) hypercholesterolemia, 2) mixed hyperlipoproteinemia. Lipid profile by ultracentrifugation was performed simultaneously with ultrasonic examination. RESULTS: Among 33 patients with hypercholesterolaemia, 7 had hepatic steatosis (21.2%), with a mean serum TG concentration significantly higher than in those patients without steatosis. Of the mixed HLP patients, 16 had hepatic steatosis (51.5%), with a mean serum TG level over twice the concentration found in patients without steatosis. We found significantly higher levels of total cholesterol and triglycerides in patients with steatosis than in those without. In the HDL fraction, the cholesterol concentration was lower (38.4 mg/dl) in cases of steatosis than in cases without (48.0 mg/dl). CONCLUSIONS: Patients with steatosis showed features characteristic of insulin resistance syndrome, i.e. higher BMI values, higher mean serum TG, and low HDL cholesterol concentrations. In patients with hypercholesterolemia and hepatic steatosis, increased serum triglycerides are associated with increased TG concentration in the VLDL fraction. Mixed HLP patients with hepatic steatosis have higher TG and cholesterol in the VLDL fraction, and in these cases a significant rise in total TG is observed.

Keywords: Hyperlipoproteinemias - classification, Hyperlipoproteinemias - metabolism, Obesity - metabolism

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750