01 May 1996
Does intralymphatic treatment of Hodgkin's disease allow the preservation of fertility? Pregnancy cases
Aleksander Danikiewicz, Małgorzata Muc-Wierzgoń, Peter HirnleMed Sci Monit 1996; 2(3): CR314-317 :: ID: 499813
Abstract
Four young women with diagnosed Hodgkin's disease (stage III b or IV) were treated with standard MOPP/ABVD chemotherapy. After 6 cycles they had residual retroperitoneal changes and to preserve fertility, therapy was subsequently continued as a single intralymphatic injection of 60 mg bleomycin in oily suspension. There were no severe adverse reactions as only transient fever and slight pain in the legs were reported. Follow-up X-rays showed a marked size reduction of retroperitoneal lymph nodes and disappearance of remaining B-symptoms. Each woman became pregnant within 2 to 14 months and gave birth to a healthy infant. Three of the women remain free of disease and one has had a recurrence in the primary site (the neck) and has been treated with second-line intravenous chemotherapy. Intralymphatic treatment of retroperitoneal lymphoma while preserving fertility may produce satisfactory results in selected patients.
Keywords: Hodgkin, treatment, Fertility
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
26 Feb 2024 : Clinical Research
Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...Med Sci Monit In Press; DOI: 10.12659/MSM.942509
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952