03 March 1997
Early side effects on normal tissue of radiotherapy for head and neck cancers correlation with activities of free radical scavenging enzymes
Dorota Tarnawska, Krzysztof Składowski, Wojciech Jacheć, Roman Tarnawski, Andrzej Tomasik, Bogusław MaciejewskiMed Sci Monit 1997; 3(2): CR199-203 :: ID: 500692
Abstract
Early side effects of radiation therapy seem to be a major limiting factor in treatment intensification for head and neck cancers. Correlations between the activity of Cu,Zn-superoxide dismutase (SOD), gluthatione peroxidase (GPX), gluthatione transferase (GST); the concentration of malonyldialdehyde (MDA), 7-ketocholesterol, and the severity of early mucosal radiation damage were studied in 90 patients treated with radical radiotherapy. Mucosal reactions were scored according to the Dische scale. Enzymatic activities were studied in erythrocytes, and concentrations of lipid oxidation were measured in blood plasma. The mean Cu,Zn-SOD activity before treatment was 947 U/g Hb, mean GPX activity 21 U/g Hb, MDA concentration in plasma 4.2 µg/l, MDA concentration in erythrocytes 0.19 µg/g Hb, and 7-ketocholesterol concentration 228 µg/l. Only gluthatione peroxidase (r=0.54) and gluthatione peroxidase/superoxide dismutase activity ratio (r=0.52) correlated with the severity of clinically observed early radiation damage. As a wide spectrum of the enzymatic activities was observed for the same level of normal tissue injury, it is not possible to predict the clinical radiosensitivity of individual patients from the estimation of the free radical enzymatic scavenging activity.
Keywords: radiation injury, Radiotherapy, gluthatione peroxidase, oxygen free radicals, Dose Fractionation
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
06 Mar 2024 : Clinical Research
Comparison of Outcomes between Single-Level and Double-Level Corpectomy in Thoracolumbar Reconstruction: A ...Med Sci Monit In Press; DOI: 10.12659/MSM.943797
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
10 Apr 2024 : Clinical Research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Dep...Med Sci Monit In Press; DOI: 10.12659/MSM.942612
06 Mar 2024 : Clinical Research
Enhanced Surgical Outcomes of Popliteal Cyst Excision: A Retrospective Study Comparing Arthroscopic Debride...Med Sci Monit In Press; DOI: 10.12659/MSM.941102
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952