30 October 1998
Role of nitric oxide in physiology and patophysiology of periodontal tissues
Zsolt M. Lohinai, Csaba SzaboMed Sci Monit 1998; 4(6): RA1089-1095 :: ID: 501940
Abstract
The purpose of our rewiew the role of nitric oxide (NO) in periodontal tissues in physiological and pathophysiological conditions. NO is produced by three isoforms of NO synthase (NOS): the constitutive, endothelial isoform, eNOS; the constitutive neuronal isoform, bNOS; and the inducible isoform, iNOS. All three isoforms are present or can be expressed in periodontal tissues. ENOS is located in the vascular endothelium, bNOS in the perivascular and soliter nerve fibers. The constitutive isoforms are present under normal (physiological) conditions. NO produced physiologically by eNOS is protective in circumdental tissues, promotes perfusion and may exert anti-inflammatory effects. The expression of iNOS is induced in inflammatory conditions, such as periodontitis. NO produced by iNOS, or peroxynitrite, its reaction product are detrimental when produced in excess in inflammation. The purpose of iNOS expression in periodontitis is presumably to produce NO and destroy the invading microorganisms. However, iNOS-derived NO or peroxynitrite may destroy the host tissues as well.Selective inhibition of iNOS may be of therapeutic utility in periodontitis.
Keywords: Nitric Oxide, Nitric Oxide Synthase
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
05 Mar 2024 : Clinical Research
Role of Critical Shoulder Angle in Degenerative Type Rotator Cuff Tears: A Turkish Cohort StudyMed Sci Monit In Press; DOI: 10.12659/MSM.943703
06 Mar 2024 : Clinical Research
Comparison of Outcomes between Single-Level and Double-Level Corpectomy in Thoracolumbar Reconstruction: A ...Med Sci Monit In Press; DOI: 10.12659/MSM.943797
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
10 Apr 2024 : Clinical Research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Dep...Med Sci Monit In Press; DOI: 10.12659/MSM.942612
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952