Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 January 1998

Assessment of 99mTc-Hepida plasma clearance test evaluation for monitoring of acute and chronic liver diseases

Jolanta Białkowska-Warzecha

Med Sci Monit 1998; 4(1): HY153-157 :: ID: 502855

Abstract

99mTc-Hepida plasma clearance test (HEP-Cl) is a specific and sensitive test of liver function, which has proved to be of much use in assessing the degree of hepatocellular damage. It can be assumed, that this test will also prove useful in monitoring the course of acute and chronic diseases of liver parenchyma and will aid in making the prognosis early in the course of the pathological process. The study was performed on 110 patients, who were divided into three groups (Group I - acute hepatitis type B, Group II - chronic active hepatitis, Group III - cirrhosis of the liver). In all patients the values of HEP-Cl were determined three times. The activity of ALT and GGTP, total bilirubin concentration, serum proteins and electrophoretic fractions were also assessed, as well as markers of infection with hepatitis B virus. The clinical condition of the patients was assessed in the beginning, and at the end of the observation period by means of physical examination. After 6 months of observation 37 patients in Group I recovered (Gr. Ia) and 7 developed chronic hepatitis type B (Gr. Ib). An increase of HEP-Cl was observed in the cases of recovery from acute hepatitis type B. In Group Ib patients exhibited a complete lack of dynamics in HEP-Cl. In the Gr. II and Gr.III effectiveness of treatment from the clinical and biochemical point of view was determined 12-18 months after the observation started. Objective examination included biochemical tests, HEP-Cl inclusive, and liverbiopsy. Youle's coefficient indicated a highly statistically significant correlation (Q=0.78) between clinical assessment and the results of HEP-Cl in chronic active hepatitis, and a lower correlation (Q=0.48) between clinical assessment and the results of HEP-Cl in cirrhosis hepatis. These data indicate that follow up by means of 99mTc-Hepida plasma clearance test is an efficient test for monitoring therapy in acute viral hepatitis type B, and chronic active hepatitis, but of less use in monitoring the course of cirrhosis of the liver.

Keywords: Cirrhosis hepatis, acute and chronic hepatitis, monitoring treatment, plasma clearance, hepida

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

26 Feb 2024 : Clinical Research  

Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...

Med Sci Monit In Press; DOI: 10.12659/MSM.942509  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750