Comparison of influence of thiopentone, propofol and midazolam on blood serum concentration of noradrenaline and cortisol in patients undergoing non-toxic struma operation
Hanna Misiołek, Ewa Wojcieszek, Anna Dyaczynska-HermanMed Sci Monit 2000; 6(2): CR319-324 :: ID: 508445
Abstract
The stress hormones plasma concentration after intravenous anesthetics (thiopentone, propofol, midazolam) administration in patients who underwent non-toxic struma operation was estimated. The goal of the study was to answer what stage of the general anesthesia and the surgery is the most dangerous for the cardiovascular system in term of stress hormones concentration and which of induction anesthetics used significantly alleviates undesirable reactions to surgical trauma and general anesthesia. 45 women aged 43I11, who underwent non-toxic struma operation and 16 women who underwent biliary gall-stones operation served as the 'study group and controls', respectively. Both groups were divided into 3 subgroups (in each a different anesthetic was used). Blood samples were taken at moments of increased stress during general anesthesia and operation. Intubation performed by laryngoscopy was found as the most stressful moment at which stress hormones are released intensively and can initiate cardiovascular disorders. According to our zasugestionowali, the suppression of the stress hormones (noradrenaline and cortisol) release was observed when propofol and midazolam were used for anesthesia induction for non-toxic struma surgery in contrast to thiopentone administration.
key words: catecholamines • anesthesia • surgical stress • propofol • midazolam • thiopentone • strumectomy
Keywords: strumectomy, thiopentone, Midazolam, Propofol, surgical stress, Anesthesia, Catecholamines
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
06 Mar 2024 : Clinical Research
Comparison of Outcomes between Single-Level and Double-Level Corpectomy in Thoracolumbar Reconstruction: A ...Med Sci Monit In Press; DOI: 10.12659/MSM.943797
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
10 Apr 2024 : Clinical Research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Dep...Med Sci Monit In Press; DOI: 10.12659/MSM.942612
06 Mar 2024 : Clinical Research
Enhanced Surgical Outcomes of Popliteal Cyst Excision: A Retrospective Study Comparing Arthroscopic Debride...Med Sci Monit In Press; DOI: 10.12659/MSM.941102
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952