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22 September 2022 : Clinical Research  

Impact of Adherence with Disease-Modifying Therapies on All-Cause Mortality Rates Among Veterans with Multiple Sclerosis

Meheroz H. Rabadi12ABCDEF*, Kimberly Just1B, Chao Xu ORCID logo3CDE

DOI: 10.12659/MSM.938116

Med Sci Monit 2022; 28:e938116


BACKGROUND: Adherence to disease-modifying therapies (DMTs) is essential for reducing multiple sclerosis (MS)-related relapses and disability. However, no known data exist regarding rates of adherence to DMTs and their impact on mortality. The present study aimed to determine the effect of adherence to DMTs on all-cause mortality in patients with MS in a real-world setting.

MATERIAL AND METHODS: We reviewed electronic records of 279 patients with MS and followed them longitudinally in our MS clinic between Januray1, 2000 and December 31, 2019. The inclusion criteria were complete electronic records along with documentation of initial and final functional outcome measures, including mortality. The exclusion criteria were incomplete electronic records and lack of documentation of initial and final functional outcome measures.

RESULTS: Of 279 patients with MS, 148 (53.0%) were non-adherent to any DMT medication(s). Of the 131 (47.0%) MS patients who were adherent, 13 (4.7%) had poor adherence and 118 (42.3%) had good adherence. More patients in the good-adherence group survived (94.9%) compared to the non-adherence group (66.9%, P<0.001). The odds of being alive were 12 times higher among those who adhered to their DMT compared to those who did not.

CONCLUSIONS: This study indicates that veterans who adhere to their DMTs are 12 times more likely to be alive than those who are non-adherent, even after adjusting for variables known to affect S-related mortality such as age at entry, MS type, MS duration, body mass index, and diabetes.

Keywords: Multiple Sclerosis, Veterans, medication adherence, Mortality



12 September 2022 : Editorial  

Editorial: Treatment with Dual Incretin Receptor Agonists to Maintain Normal Glucose Levels May Also Maintain Normal Weight and Control Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)

Ana Luisa Ordóñez-Vázquez, Sofía Murúa Beltrán-Gall, Shreya C. Pal, Nahum Méndez-Sánchez
Liver Research Unit, Medica Sur Clinic Foundation, Mexico City, Mexico

DOI: 10.12659/MSM.938365

Med Sci Monit 2022; 28:e938365


16 September 2022 : Review article  

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Med Sci Monit In Press; DOI: 10.12659/MSM.938141  

12 September 2022 : Clinical Research  

Effect of Vitamin D Concentration on Course of COVID-19

Med Sci Monit In Press; DOI: 10.12659/MSM.937741  

In Press

23 Sep 2022 : Review article  

A Review of the Role of Ultrasound Radiomics and Its Application and Limitations in the Investigation of Th...

Med Sci Monit In Press; DOI: 10.12659/MSM.937738  

23 Sep 2022 : Review article  

Review of the Long-Term Outcomes of Guided Bone Regeneration and Autologous Bone Block Augmentation for Ver...

Med Sci Monit In Press; DOI: 10.12659/MSM.937433  

22 Sep 2022 : Clinical Research  

Comparison of Incremental Shuttle Walking Test, 6-Minute Walking Test, and Cardiopulmonary Exercise Stress ...

Med Sci Monit In Press; DOI: 10.12659/MSM.938140  

21 Sep 2022 : Clinical Research  

Questionnaire-Based Study on the Prevalence, Awareness, and Preventive Measures of Occupational Hazards Amo...

Med Sci Monit In Press; DOI: 10.12659/MSM.938084  

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750