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10 June 2022: Clinical Research

Association Between Serum Homocysteine Levels and Severity of Diabetic Kidney Disease in 489 Patients with Type 2 Diabetes Mellitus: A Single-Center Study

Juan Wu 1ABCDEF* , Dengke Liu 12BC* , Liu Yang 3B , Jianping Liu 1BC*

DOI: 10.12659/MSM.936323

Med Sci Monit 2022; 28:e936323

Table 3 Hcy was more closely related to eGFR and CKD stages than to UACR and albuminuria stages.

HcyCKD stagesAlbuminuria stages
Ager=0.261, P*** r=0.264, P*** r=0.214, P***
BMIr=0.036, P=0.224r=0.035, P=0.238r=0.035, P=0.239
SBPr=0.148, P*** r=0.216, P*** r=0.253, P***
DBPr=0.065, P=0.027* r=0.132, P*** r=0.174, P***
FPGr=−0.167, P*** r=−0.157, P*** r=−0.093, P=0.002**
FCPr=0.262, P*** r=0.252, P*** r=0.164, P***
HbA1cr=−0.199, P*** r=−0.136, P*** r=−0.061, P=0.039*
TCr=−0.171, P*** r=−0.108, P*** r=−0.043, P=0.142
TGr=−0.025, P=0.399r=0.078, P=0.008** r=0.077, P=0.009**
HDLr=−0.159, P*** r=−0.143, P*** r=−0.082, P=0.120
LDLr=−0.173, P*** r=−0.132, P*** r=−0.105, P***
eGFRr=−0.581, P*** r=−0.571, P***
SUAr=0.358, P*** r=0.423, P*** r=0.352, P***
UACRr=0.299, P*** r=0.757, P***
Hcyr=0.487, P*** r=0.389, P***
FAr=−0.320, P*** r=−0.287, P*** r=−0.249, P***
VitB12r=−0.123, P*** r=0.052, P=0.079r=−0.055, P=0.060
Duration of diabetesr=0.231, P*** r=0.358, P*** r=0.326, P***
CKD – chronic kidney disease; BMI – body mass index; SBP – systolic blood pressure; DBP – diastolic blood pressure; FPG – fasting plasma glucose; FCP – fasting C peptide; HbA1c – glycosylated hemoglobin A1c; TC – total cholesterol; TG – triglyceride; HDL – high-density lipoprotein; LDL – low-density lipoprotein; eGFR – estimated glomerular filtration rate; SUA – serum uric acid; UACR – urinary albumin/creatinine ratio; Hcy – homocysteine; FA – folic acid; VitB12 – vitamin B12;
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** P
*** P

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750