21 June 2022: Clinical Research
Prognostic Significance of Preoperative Integrated Liver Inflammatory Score in Patients with Hepatocellular Carcinoma
Biao Wu 12ABCDEF* , Yumeng Wu 2ABC* , Xianlin Guo 12BCF , Yifei Liu 3ACD , Yanping Yue 2BCF , Wenjing Zhao 2ABG , Jibin Liu 2ADG , Xuming Wu 4ABC , Aiguo Shen 2ACEG* , Suqing Zhang 1ACEFG*DOI: 10.12659/MSM.937005
Med Sci Monit 2022; 28:e937005
Table 1 Correlation of ILIS with clinicopathological characteristics.
| Clinical pathological indexes | Training cohort (275 cases) | Validation cohort (157 cases) | ||||
|---|---|---|---|---|---|---|
| Low | High | P | Low | High | P | |
| Age (years) | 0.780 | 0.483 | ||||
| 59 | 87 | 48 | 34 | |||
| ≥55 | 50 | 79 | 48 | 27 | ||
| Gender | 0.388 | 0.875 | ||||
| Female | 19 | 36 | 21 | 14 | ||
| Male | 90 | 130 | 75 | 47 | ||
| HBV | 0.726 | 0.199 | ||||
| Absent | 43 | 62 | 38 | 18 | ||
| Present | 66 | 104 | 58 | 43 | ||
| Cirrhosis | 0.116 | 0.394 | ||||
| Absent | 40 | 46 | 33 | 17 | ||
| Present | 69 | 120 | 63 | 44 | ||
| Tumour size (cm) | 0.052 | |||||
| ≤5 | 77 | 93 | 71 | 37 | ||
| 5–10 | 29 | 56 | 21 | 17 | ||
| >10 | 3 | 17 | 2 | 6 | ||
| No. of tumour nodules | 0.824 | 0.907 | ||||
| 1 | 93 | 140 | 86 | 55 | ||
| ≥2 | 16 | 26 | 10 | 6 | ||
| Differentiation | ||||||
| Well | 31 | 34 | 22 | 9 | ||
| Moderate | 60 | 78 | 62 | 35 | ||
| Poor | 18 | 54 | 12 | 17 | ||
| Vascular tumor thrombus | 0.943 | 0.097 | ||||
| Absent | 81 | 124 | 77 | 55 | ||
| Present | 28 | 42 | 19 | 6 | ||
| Child-Pugh class | ||||||
| A | 109 | 150 | 95 | 55 | ||
| B | 0 | 16 | 1 | 6 | ||
| BCLC stage | ||||||
| 0 | 14 | 12 | 13 | 12 | ||
| A | 90 | 129 | 70 | 29 | ||
| B | 5 | 25 | 13 | 20 | ||