21 June 2022: Clinical Research
Prognostic Significance of Preoperative Integrated Liver Inflammatory Score in Patients with Hepatocellular Carcinoma
Biao Wu 12ABCDEF* , Yumeng Wu 2ABC* , Xianlin Guo 12BCF , Yifei Liu 3ACD , Yanping Yue 2BCF , Wenjing Zhao 2ABG , Jibin Liu 2ADG , Xuming Wu 4ABC , Aiguo Shen 2ACEG* , Suqing Zhang 1ACEFG*DOI: 10.12659/MSM.937005
Med Sci Monit 2022; 28:e937005
Table 2 Univariate and multivariate analyses of prognostic factors with OS in patients with HCC.
| Variable | Training cohort | |||
|---|---|---|---|---|
| Univariate | Multivariate | |||
| HR (95% CI) | P | HR (95% CI) | P | |
| ILIS (high vs low) | 0.554 (0.375–0.818) | 0.665 (0.444–0.997) | ||
| Age ( | 1.235 (0.866–1.761) | 0.244 | ||
| Gender ( male vs female) | 1.296 (0.654–2.565) | 0.457 | ||
| HBV (absent vs present) | 0.817 (0.569–1.173) | 0.273 | ||
| Cirrhosis (absent vs present) | 0.708 (0.490–1.023) | 0.066 | ||
| Tumour size (10 cm) | 0.301 (0.174–0.520) | 0.465 (0.260–0.833) | ||
| No. of tumour nodules (1 vs ≥2) | 0.629 (0.402–0.983) | |||
| Differentiation (well vs moderate vs poor) | 1.295 (1.006–1.669) | |||
| Vascular tumor thrombus (absent vs present) | 0.560 (0.383–0.820) | |||
| Child-Pugh class (A vs B) | 0.889 (0.621–1.273) | 0.520 | ||
| BCLC stage (0 vs A vs B) | 4.040 (2.107–7.745) | 0.516 (0.318–0.839) | ||
| ILIS (high vs low) | 3.566 (1.694–7.507) | 0.574 (0.343–0.961) | ||
| Age ( | 1.097 (0.686–1.754) | 0.700 | ||
| Gender ( male vs female) | 1.225 (0.682–2.200) | 0.498 | ||
| HBV (absent vs present) | 0.815 (0.505–1.315) | 0.403 | ||
| Cirrhosis (absent vs present) | 1.281 (0.762–2.152) | 0.350 | ||
| Tumour size (10 cm) | 1.493 (1.021–2.184) | |||
| No. of tumour nodules (1 vs ≥2) | 2.021 (1.061–3.852) | |||
| Differentiation (well vs moderate vs poor) | 1.418 (0.984–2.044) | 0.061 | ||
| Vascular tumor thrombus (absent vs present) | 2.001 (1.158–3.460) | |||
| Child-Pugh class (A vs B) | 0.680 (0.248–1.867) | 0.454 | ||
| BCLC stage (0 vs A vs B) | 0.424 (0.251–0.715) | 0.498 (0.282–0.879) | ||