29 August 2022: Database Analysis
Transcriptome Analysis of Peripheral Blood Mononuclear Cells Response in Patients with Severe COVID-19 Reveals Crucial Genes Regulating Protein Ubiquitination
Jinfeng Huang 1ABCDEF* , Ruobing Li 2EF* , Jie Cheng 3B* , Peilin Zhen 1AB*DOI: 10.12659/MSM.937532
Med Sci Monit 2022; 28:e937532
Table 3 Biological processes enrichment analysis of genes in cluster 1.
| Term | Genes | P-value | FDR |
|---|---|---|---|
| Protein ubiquitination | ITCH, TRIM21, RNF130, FBXO11, UBE2J1, ASB16 | 0.026×10 | 0.0138×10 |
| Negative regulation of NF-kappaB transcription factor activity | ITCH, TRIM21 | 0.025 | 0.67 |
| Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | ITCH, ANAPC1 | 0.053 | 0.85 |
| Ubiquitin-dependent protein catabolic process | ITCH, FBXO11 | 0.063 | 0.85 |