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10 November 2022: Clinical Research

Thyroid-Stimulating Hormone as a Biomarker for Stress After Thyroid Surgery: A Prospective Cohort Study

Hua Hong AB , Jeonghun Lee ADE*

DOI: 10.12659/MSM.937957

Med Sci Monit 2022; 28:e937957

Table 1 Characteristics of the enrolled patients.

CharacteristicsValues
AgeMean±SD46.7±9.84
HeightMean±SD163.4±7.23
Body weight (kg) 1Mean±SD63.5±11.76
Body weight (kg) 263.6±11.26
SexMale22 (20.8%)
Female84 (79.2%)
ApproachOpen88 (83%)
Robotic/endoscopic17 (16%)
Extent of thyroid surgeryTotal58 (54.7%)
Less than total48 (45.3%)
Levothyroxine 1Medication (Mean±SD, μg)89 (113±30.4)
No medication17 (16.0%)
Levothyroxine 2Medication (Mean±SD, μg)89 (108.1±32.7)
No medication17 (16.0%)
PathologyPapillary cancer102 (96.2%)
Follicular cancer1 (0.9%)
Medullary cancer1 (0.9%)
Benign goiter2 (1.9%)
Tumor size (cm)Mean±SD (mm)10.3±7.86
T stage (%)T184 (79.2%)
T27 (6.6.%)
T38 (7.5%)
T43 (2.8%)
Tx4 (3.8%)
N stage (%)N058 (54.7%)
N1a28 (26.4%)
N1b11 (10.4%)
Nx9 (8.5%)
M stage (%)M0105 (99.1%)
M11 (0.9%)
Preoperative TSHMean±SD (μIU/mL)2.8±7.13
TSH 1Mean±SD2.7±5.63
TSH 2Mean±SD2.6±7.68
Free T4 1Mean±SD (ng/dL)1.34±0.28
Free T4 2Mean±SD1.44±0.24
T3 1Mean±SD (ng/dL)99.9±17.7
T3 2Mean±SD102.5±15.35
KDSI 1Mean±SD (ng/dL)94.2±78.61
KDSI 2Mean±SD91.5±71.82
SOSS 1Mean±SD (ng/dL)20.2±10.88
SOSS 2Mean±SD18.6±9.49
SRRS 1Mean±SD (ng/dL)148.2±108.03
SRRS 2Mean±SD109.8±102.22
Stress event
1 periodCases (%)8 (7.5%)
2 periodCases (%)7 (6.6%)
SOSS (category)12
Low risk, cases (%)73 (68.9%)79 (74.5%)
Challenge02 (1.9%)
Fragile11 (10.4%)20 (8.5%)
High risk22 (20.8%)38 (15.1%)
Life event, stressDistressChange in work hours2 (13.3%)
Personal illness1 (6.6%)
Change in sleeping habits1 (6.6%)
Death of close family member2 (13.3%)
Business readjustment3 (20%)
Trouble with in-laws1 (6.6%)
Trouble with boss1 (6.6%)
Other stress3 (20%)
EustressChange in recreation1 (6.6%)
KDSI – Korean version of Daily Stress Inventory; TSH – thyroid stimulating hormone; SD – standard deviation; SRRS – Social Readjustment Rating Scale; SOSS – Stress Overload Scale-Short.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750