21 November 2022>: Clinical Research
Long-Term Effect of Pancreaticoduodenectomy Combined with Revascularization for Resectable Pancreatic Carcinoma in Elderly Patients
Jiali Yang 1ABCDEF* , Zhengrong Xu 2ABCD* , Junfeng Zhang 1CD , Yao Zheng 1CD , Jianyou Gu 1AC , Qiang Zhou 1CD , Xianxing Wang 1CD , Shixiang Guo 1DF , Hongyu Zhang 3AD , Shengkai Chen 1ADG* , Huaizhi Wang 1ADG*DOI: 10.12659/MSM.938443
Med Sci Monit 2022; 28:e938443
Table 2 Perioperative and pathologic characteristics of the PDAC patients who underwent PDR according to age.
Variables | Total (n=185) | Age <60 y (n=103) | 60 y ≤ Age <70 y (n=55) | Age ≥70 y (n=27) | P value |
---|---|---|---|---|---|
Type of PD* | 0.851 | ||||
PPPD | 29 (15.7) | 15 (14.6) | 10 (18.2) | 4 (14.8) | |
Whipple | 156 (83.3) | 88 (85.4) | 45 (81.8) | 23 (85.2) | |
Vascular invasion site* | 0.755 | ||||
PV | 23 (12.4) | 12 (11.7) | 7 (12.7) | 4 (14.8) | |
Confluence of SMV and PV | 83 (44.9) | 48 (46.6) | 26 (47.3) | 9 (33.3) | |
SMV | 79 (42.7) | 43 (41.7) | 22 (40.0) | 14 (51.9) | |
Types of venous reconstruction* | 0.073 | ||||
Interposition graft | 70 (37.8) | 44 (42.7) | 22 (40.0) | 4 (14.8) | |
End-to-end anastomosis | 101 (54.6) | 51 (49.5) | 30 (54.5) | 20 (74.1) | |
Primary closure | 14 (7.6) | 8 (7.8) | 3 (5.5) | 3 (11.1) | |
Ligation of splenic vein* | 26 (14.1) | 16 (15.5) | 6 (10.9) | 4 (14.8) | 0.764 |
Combined organ resection* | 11 (5.9) | 6 (5.8) | 2 (3.6) | 3 (11.1) | 0.386 |
Operation duration (min)** | 460 (178–960) | 470 (245–960) | 458 (277–814) | 410 (178–640) | 0.063 |
Operative blood loss (ml)** | 600 (200–7200) | 600 (200–7200) | 600 (200–4000) | 600 (200–1700) | 0.566 |
Operative blood transfusion (ml)** | 400 (0–3500) | 400 (0–3500) | 300 (0–2550) | 400 (0–1200) | 0.689 |
Postoperative hospital stay (days)** | 20 (5–164) | 21 (5–164) | 19 (8–36) | 19 (6–42) | 0.246 |
ICU stay (days)** | 3 (1–90) | 3 (1–90) | 3 (1–25) | 3 (2–13) | 0.035 |
Tumor size (cm)** | 3 (2.1–4.0) | 3 (2.1–4.0) | 3 (3.0–3.5) | 3.5 (2.5–4.0) | 0.588 |
Degree of differentiation* | 0.783 | ||||
Well | 14 (7.6) | 5 (4.9) | 3 (5.5) | 13 (48.1) | |
Moderate | 130 (70.3) | 78 (75.7) | 39 (70.9) | 13 (48.1) | |
Poor | 41 (22.2) | 20 (19.4) | 13 (23.6) | 8 (29.6) | |
Pathological invasion of PV-SMV* | 38 (20.5) | 17 (16.5) | 12 (21.8) | 9 (33.3) | 0.150 |
Neurological invasion* | 90 (48.6) | 55 (53.4) | 22 (40.0) | 13 (48.1) | 0.275 |
Resection margin* | 0.505 | ||||
R0 | 176 (95.1) | 98 (95.1) | 51 (92.7) | 51 (92.7) | |
R1 | 9 (4.9) | 5 (4.9) | 4 (7.3) | 0 | |
TNM staging* | 0.837 | ||||
I | 105 (56.8) | 55 (53.3) | 34 (61.8) | 16 (59.3) | |
II | 57 (30.8) | 34 (33.0) | 15 (27.3) | 8 (29.6) | |
III | 13 (7.0) | 9 (8.7) | 2 (3.6) | 2 (7.4) | |
IV | 10 (5.4) | 5 (4.9) | 4 (7.3) | 1 (3.7) | |
T staging* | 0.346 | ||||
T1 | 41 (22.1) | 22 (21.3) | 14 (25.5) | 5 (18.5) | |
T2 | 109 (58.9) | 56 (54.3) | 33 (60.0) | 20 (74.0) | |
T3 | 30 (16.2) | 22 (21.3) | 6 (10.9) | 2 (7.4) | |
T4 | 5 (2.7) | 3 (2.9) | 2 (3.6) | 0 | |
N staging* | 0.267 | ||||
N0 | 131 (70.8) | 72 (59.9) | 42 (76.4) | 17 (63.0) | |
N1 | 44 (23.8) | 23 (22.3) | 13 (23.6) | 8 (29.6) | |
N2 | 10 (5.4) | 8 (7.8) | 0 | 2 (7.4) | |
Distant metastasis* | 10 (5.4) | 5 (4.9) | 4 (7.3) | 1 (3.7) | 0.900 |
* Results are presented as a number (percentage); ** results are presented as the median (range). |