14 December 2020>: Review Articles
Cell Sources and Influencing Factors of Liver Regeneration: A Review
Chengzhan Zhu 12AEG , Bingzi Dong 2FG , Leqi Sun 3EF , Yixiu Wang 1BCE , Shuhai Chen 4AEF*DOI: 10.12659/MSM.929129
Med Sci Monit 2020; 26:e929129
Figure 1 The schematic overview of hepatocyte-mediated liver regeneration (LR). In hepatic lobules, several types of mature hepatocytes have the characteristics of high replication capacity and plasticity. Axin2+ hepatocytes located around the central vein had stem cell-like characteristics; Mfsd2a+ hepatocytes in the portal vein triad region are low in quantity but can be activated, apparently, upon PH or chronic liver injury; a portion of hepatocytes surrounding the portal vein can directly differentiate into biliary cells; Sox9+/HNF4α+ hybrid hepatocytes are located near the branches of the portal vein and terminal biliary tract and can become hepatocytes and BECs after liver injury; Lgr5+ pericentral hepatocytes have a long life and contribute to the homeostasis of the liver; hepatocytes marked by telomerase expression are the main source of hepatocytes in normal liver homeostasis and injury-induced LR.