01 January 2000
Nitric oxide increases gene expression of Ca(2+)-ATPase in myocardial and skeletalmuscle sarcoplasmic reticulum: physiological implications.
Igor Yu Malyshev, Nadezhda P. Aymasheva, Eugeny B. Malenyuk, Georgy L. Khaspekov, Eugenia B. Manukhina, Vasak D. Mikoyan, Ludmila N. Kubrina, Antoly F. VaninMed Sci Monit 2000; 6(3): BR480-485 :: ID: 421322
Abstract
The aim of the study was to verify the hypothesis that NO-dependent regulationof sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) gene expression can play an important role in preventionof calcium overload under the influence of detrimental factors. It was shown that 2 hours after the administrationof the NO donor dinitrosyl iron complex (DNIC), the gene expression of myocardial SERCA was increasedby 20% as compared to the control. In skeletal muscles, the maximum increase in SERCA expression wasobserved in 6 hours and amounted to 156% as compared with the initial value. Simultaneously DNIC enhancedthe resistance of isolated heart and the organism as a whole to damaging effects of intracellular calciumoverload induced by post-ischemic reperfusion or vigorous exercise, respectively. The results obtainedconfirm the existence of NO-dependent activation of SERCA expression and the important role of this mechanismin restriction of calcium overload.
Keywords: Ca(2+)-Transporting ATPase, Gene Expression Regulation, Enzymologic, Iron, Muscle, Skeletal, Myocardium, Nitric Oxide, Nitric Oxide Donors, Nitrogen Oxides, Rats, Wistar, Research Support, Non-U.S. Gov, Sarcoplasmic Reticulum, Time Factors
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
14 Mar 2024 : Clinical Research
Differential DHA and EPA Levels in Women with Preterm and Term Births: A Tertiary Hospital Study in IndonesiaMed Sci Monit In Press; DOI: 10.12659/MSM.943895
15 Mar 2024 : Clinical Research
Evaluation of an Optimized Workflow for the Radiofrequency Catheter Ablation of Paroxysmal Atrial FibrillationMed Sci Monit In Press; DOI: 10.12659/MSM.943526
09 May 2024 : Review article
A Review of the Current Status of Disease-Modifying Therapies and Prevention of Alzheimer’s DiseaseMed Sci Monit In Press; DOI: 10.12659/MSM.945091
09 Apr 2024 : Clinical Research
Correlation between Thalamocortical Tract and Default Mode Network with Consciousness Levels in Hypoxic-Isc...Med Sci Monit In Press; DOI: 10.12659/MSM.943802
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952