03 March 2023 : Database Analysis
[In Press] Reinfections from SARS-CoV-2: A Retrospective Study from the Gyncentrum Genetic Laboratory in Sosnowiec, Poland, April 2020 to July 2022Emilia Morawiec12ABEF, Anna Bednarska-Czerwińska234B, Adam Pudełko2B, Nikola Zmarzły4CD, Ewa Rojczyk52DE, Krzysztof Madej6F, Dawid Sobański47E, Rafał Staszkiewicz48E, Piotr Ossowski4E, Anna Boroń-Kaczmarska9C, Karolina Zapletal-Pudełko2F, Tomasz Sirek410F, Paweł Wojciech Bogdał411F, Dariusz Boroń4121310D, Beniamin Oskar Grabarek24121013CDEF
Med Sci Monit In Press; DOI: 10.12659/MSM.939452
Available online: 2023-03-03, In Press, Corrected Proof
Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule
The increasing number of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfections has opened a new research direction related to analyzing long-term immune response and accurately characterizing individual cases of reinfection to understand its mechanism and estimate the risk of widespread reinfection both locally and globally. This retrospective study from the Gyncentrum Genetic Laboratory in Sosnowiec, Poland aimed to evaluate reinfections from SARS-CoV-2 between April 2020 and July 2022.
MATERIAL AND METHODS
The study extended the previously published report on SARS-CoV-2 infection cases in Poland by analyzing 8041 reinfections diagnosed with real-time reverse transcription-polymerase chain reaction (RT-PCR) assay. Data were collected on the amount of time elapsed from the first infection to the next and, based on these data, all results were divided into several groups for statistical analysis: 0-44, 45-90, 91-200, 201-310, 311-420, and >420 (days).
The study showed that of the 8041 patients who experienced reinfection, the vast majority (5505) became reinfected more than 310 days after the original infection, even though the average time between infections was 354.3 days. Statistical analysis revealed that the risk of SARS-CoV-2 reinfection increases with time and that this relationship becomes statistically significant after the 200th day following the initial infection (p<0.01).
We have shown that acquired immunity to SARS-CoV-2 infection is relatively short-lived – it starts diminishing about 6 months after the initial positive test. Moreover, the risk of reinfection is very high more than 1 year after the initial infection.
Keywords: COVID-19 Nucleic Acid Testing; Reinfection; Retrospective Studies; SARS-CoV-2
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