06 February 2022: Clinical Research
Cognitive Dysfunction and Health-Related Quality of Life in Patients with End-Stage Renal Disease Undergoing Hemodialysis in Comparison with Patients Undergoing Peritoneal Dialysis: A Cross-Sectional Study
Bin Zeng 1ABCDEFG , Qiaoling Wang 1BCD , Shengkai Wu 1BCD , Sefen Lin 1BCD , Yanxian Li 1BCD , Wenying Jiang 1ABCDEFG , Ruifeng Guo 1BCD , Fenhui Zhou 1BCD , Kunzhe Lin 2AE*DOI: 10.12659/MSM.934282
Med Sci Monit 2022; 28:e934282
Supplementary Table 1 Effects of hemodialysis and peritoneal dialysis on cognition dysfunction and HRQOL.
| Measure | Variable | β | S.E | t | P | 95% CI | |
|---|---|---|---|---|---|---|---|
| Lower | Upper | ||||||
| MoCA | MODEL1 | ||||||
| Intercept | 32.42 | 1.25 | 26.04 | 29.96 | 34.87 | ||
| Dialysis modality (Peritoneal dialysis vs Hemodialysis) | −8.35 | 0.76 | −11.02 | −9.85 | −6.86 | ||
| MODEL2 | |||||||
| Intercept | 43.04 | 1.99 | 21.61 | 39.12 | 46.97 | ||
| Gender (female vs male) | −1.71 | 0.72 | −2.36 | 0.019 | −3.13 | −0.28 | |
| Age | −0.18 | 0.03 | −5.96 | −0.23 | −0.12 | ||
| Dialysis modality (peritoneal dialysis vs hemodialysis) | −7.16 | 0.74 | −9.71 | −8.61 | −5.70 | ||
| MODEL3 | |||||||
| Intercept | 33.73 | 4.30 | 7.85 | 25.26 | 42.19 | ||
| Gender (female vs male) | −1.25 | 0.71 | −1.76 | 0.080 | −2.65 | 0.15 | |
| Age, years | −0.13 | 0.04 | −3.21 | 0.002 | −0.20 | −0.05 | |
| BMI | 0.24 | 0.12 | 1.92 | 0.055 | −0.01 | 0.48 | |
| Marital status (unmarried vs married) | −1.49 | 1.50 | −0.99 | 0.321 | −4.44 | 1.46 | |
| Educational level | 2.48 | 0.55 | 4.47 | 1.39 | 3.57 | ||
| Income level | −0.02 | 0.65 | −0.03 | 0.974 | −1.30 | 1.26 | |
| Diabetes (yes) | −1.11 | 0.78 | −1.43 | 0.155 | −2.64 | 0.42 | |
| Duration of kidney disease, years | −0.15 | 0.09 | −1.75 | 0.081 | −0.33 | 0.02 | |
| Duration of dialysis, months | 0.01 | 0.02 | 0.64 | 0.520 | −0.02 | 0.05 | |
| Dialysis frequency, weeks | 0.11 | 1.05 | 0.11 | 0.916 | −1.96 | 2.18 | |
| Dialysis modality (peritoneal dialysis vs hemodialysis) | −7.02 | 0.89 | −7.85 | −8.78 | −5.26 | ||
| SF-36 | MODEL1 | ||||||
| Intercept | 37.40 | 1.46 | 25.69 | 34.53 | 40.27 | ||
| Dialysis modality (peritoneal dialysis vs hemodialysis) | −10.20 | 0.89 | −11.50 | −11.94 | −8.45 | ||
| MODEL2 | |||||||
| Intercept | 48.45 | 2.37 | 20.48 | 43.80 | 53.11 | ||
| Gender (female vs male) | −1.40 | 0.86 | −1.63 | 0.104 | −3.09 | 0.29 | |
| Age, years | −0.19 | 0.04 | −5.47 | −0.26 | −0.12 | ||
| Dialysis modality (peritoneal dialysis vs hemodialysis) | −9.00 | 0.88 | −10.29 | −10.73 | −7.28 | ||
| MODEL3 | |||||||
| Intercept | 41.57 | 5.10 | 8.15 | 31.53 | 51.61 | ||
| Gender (female vs male) | −0.97 | 0.84 | −1.15 | 0.251 | −2.63 | 0.69 | |
| Age, years | −0.12 | 0.05 | −2.46 | 0.015 | −0.21 | −0.02 | |
| BMI | 0.31 | 0.15 | 2.13 | 0.034 | 0.02 | 0.60 | |
| Marital status (unmarried vs married) | −1.74 | 1.78 | −0.98 | 0.330 | −5.24 | 1.77 | |
| Educational level | 1.80 | 0.66 | 2.74 | 0.007 | 0.51 | 3.09 | |
| Income level | −0.91 | 0.77 | −1.17 | 0.242 | −2.43 | 0.61 | |
| Diabetes (yes) | −2.76 | 0.92 | −2.99 | 0.003 | −4.57 | −0.94 | |
| Duration of kidney disease, years | −0.27 | 0.11 | −2.62 | 0.009 | −0.48 | −0.07 | |
| Duration of dialysis, months | −0.05 | 0.02 | −2.13 | 0.034 | −0.09 | −0.00 | |
| Dialysis frequency, weeks | 0.66 | 1.25 | 0.53 | 0.597 | −1.79 | 3.11 | |
| Dialysis modality (peritoneal dialysis vs hemodialysis) | −8.67 | 1.06 | −8.17 | −10.76 | −6.58 | ||
| KDTA | MODEL1 | ||||||
| Intercept | 38.19 | 1.20 | 31.92 | 35.83 | 40.54 | ||
| Dialysis modality (peritoneal dialysis vs hemodialysis) | −8.67 | 0.73 | −11.90 | −10.10 | −7.23 | ||
| MODEL2 | |||||||
| Intercept | 47.68 | 1.93 | 24.68 | 43.88 | 51.49 | ||
| Gender (female vs male) | −1.21 | 0.70 | −1.72 | 0.087 | −2.59 | 0.18 | |
| Age, years | −0.16 | 0.03 | −5.75 | −0.22 | −0.11 | ||
| Dialysis modality (peritoneal dialysis vs hemodialysis) | −7.64 | 0.72 | −10.70 | −9.05 | −6.24 | ||
| MODEL3 | |||||||
| Intercept | 40.62 | 4.15 | 9.80 | 32.45 | 48.78 | ||
| Gender (female vs male) | −0.88 | 0.68 | −1.29 | 0.199 | −2.23 | 0.47 | |
| Age, years | −0.10 | 0.04 | −2.68 | 0.008 | −0.18 | −0.03 | |
| BMI | 0.23 | 0.12 | 1.89 | 0.060 | −0.01 | 0.46 | |
| Marital status (unmarried vs married) | −1.15 | 1.45 | −0.79 | 0.428 | −4.00 | 1.70 | |
| Educational level | 1.73 | 0.54 | 3.24 | 0.001 | 0.68 | 2.79 | |
| Income level | −0.42 | 0.63 | −0.66 | 0.509 | −1.65 | 0.82 | |
| Diabetes (yes) | −1.79 | 0.75 | −2.39 | 0.017 | −3.27 | −0.32 | |
| Duration of kidney disease, years | −0.23 | 0.09 | −2.67 | 0.008 | −0.39 | −0.06 | |
| Duration of dialysis, months | −0.04 | 0.02 | −2.45 | 0.015 | −0.08 | −0.01 | |
| Dialysis frequency, weeks | 1.11 | 1.01 | 1.09 | 0.276 | −0.89 | 3.10 | |
| Dialysis modality (peritoneal dialysis vs hemodialysis) | −7.55 | 0.86 | −8.75 | −9.25 | −5.85 | ||
| CI – confidential interval; BMI – body mass index; MoCA – Montreal Cognitive Assessment; SF-36 – Short Form-36; KDTA – kidney disease-related quality of life assessment. Model 1 – the univariate linear regression; Model 2 – gender and age were adjusted; Model 3 – gender, age, BMI, marital status, education level, income level, presence of diabetes, duration of kidney disease, duration of dialysis, and dialysis frequency were adjusted. | |||||||