13 February 2022>: Clinical Research
Gas Chromatography and Flame-Ionization Detection of Non-Cholesterol Sterols as Indicators of Cholesterol Absorption and Synthesis in 158 Chinese Individuals with Normolipidemia, Hyperlipidemia, and Familial Hypercholesterolemia
Zhi-Zhao Li 1DE* , Qi-Hui Wang 2C , Yang Liu 2C , Lv-Ya Wang 3A , Zhen-Qiu Yu 3A , Qiong Huang 4B , Jing Zhang 5BDOI: 10.12659/MSM.934471
Med Sci Monit 2022; 28:e934471
Table 4 Results of receiver operating characteristic curve for healthy group (n=64) and dyslipidemia group (n=69).
Item | AUC | SE | 95% CT | z | P | Youden Index | Associated criterion | Sensitivity (%) | Specificity (%) |
---|---|---|---|---|---|---|---|---|---|
TC (mmol/L) | 0.730 | 0.043 | 0.646–0.803 | 5.356 | 0.361 | >5.73 | 37.68 | 98.44 | |
TG (mmol/L) | 0.833 | 0.038 | 0.759–0.892 | 8.675 | 0.725 | >1.7 | 72.46 | 100.00 | |
Desmosterol (%) | 0.524 | 0.051 | 0.435–0.611 | 0.470 | 0.638 | 0.106 | >0.19 | 30.88 | 79.69 |
Model 1 | 0.960 | 0.015 | 0.910–0.986 | 30.362 | 0.821 | >0.61 | 86.76 | 95.31 | |
Model 2 | 0.728 | 0.044 | 0.644–0.802 | 5.138 | 0.404 | >−0.17 | 77.94 | 62.50 | |
Model 1: TC+TG+desmosterol; Model 2: squalene+desmosterol+lathosterol+campesterol+stigmasterol+sitosterol. AUC – area under the ROC curve; SE – standard error; TC – total cholesterol; TG – triglycerides. |