20 April 2022>: Clinical Research
Effects of Interaction Between Gestational Hypertension and History of Preterm Birth on the Risk of Preterm Birth: An Analysis Based on the National Vital Statistics System Database
Xiaoqin Cao 1AE , Daoming Zu 2BCD , Yang Liu 1AE*DOI: 10.12659/MSM.935094
Med Sci Monit 2022; 28:e935094
Table 5 Logistic regression analyses of the interaction between GH and HPB on preterm birth in different ages and number of fetus.
GH | HPB | Model 1 | Model 2 | Model 3 | Interaction for Model 3 | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
OR | 95% CI | P | OR | 95% CI | P | OR | 95% CI | P | ||||
No | No | Ref | Ref | |||||||||
No | Yes | 3.980 | 3.374–4.695 | 3.903 | 3.307–4.607 | 3.246 | 2.716–3.879 | RERI (95% CI) | 1.739 (−1.749–5.227) | |||
Yes | No | 2.176 | 2.043–2.317 | 2.172 | 2.039–2.314 | 2.349 | 2.195–2.514 | AP (95% CI) | 0.274 (−0.130–0.679) | |||
Yes | Yes | 7.044 | 4.275–11.608 | 6.691 | 4.054–11.045 | 6.334 | 3.676–10.916 | S (95% CI) | 1.484 (0.763–2.883) | |||
No | No | Ref | Ref | |||||||||
No | Yes | 3.656 | 3.565–3.748 | 3.429 | 3.343–3.516 | 3.262 | 3.175–3.352 | RERI (95% CI) | 1.431 (0.993–1.870) | |||
Yes | No | 2.562 | 2.519–2.605 | 2.569 | 2.527–2.613 | 2.631 | 2.584–2.680 | AP (95% CI) | 0.226 (0.172–0.281) | |||
Yes | Yes | 6.629 | 6.222–7.062 | 6.261 | 5.874–6.673 | 6.325 | 5.908–6.772 | S (95% CI) | 1.368 (1.257–1.448) | |||
No | No | Ref | Ref | |||||||||
No | Yes | 3.624 | 3.522–3.730 | 3.357 | 3.261–3.456 | 3.295 | 3.193–3.400 | RERI (95% CI) | 1.396 (0.925–1.866) | |||
Yes | No | 2.844 | 2.786–2.904 | 2.806 | 2.749–2.865 | 2.675 | 2.615–2.737 | AP (95% CI) | 0.219 (0.161–0.278) | |||
Yes | Yes | 7.061 | 6.605–7.548 | 6.522 | 6.098–6.976 | 6.366 | 5.921–6.844 | S (95% CI) | 1.352 (1.236–1.478) | |||
≥ | ||||||||||||
No | No | Ref | Ref | |||||||||
No | Yes | 3.143 | 3.044–3.245 | 3.004 | 2.908–3.102 | 3.042 | 2.939–3.149 | RERI (95% CI) | 0.717 (0.289–1.146) | |||
Yes | No | 2.987 | 2.918–3.057 | 2.925 | 2.857–2.994 | 2.729 | 2.660–2.800 | AP (95% CI) | 0.131 (0.062–0.199) | |||
Yes | Yes | 5.988 | 5.581–6.425 | 5.618 | 5.234–6.031 | 5.489 | 5.087–5.921 | S (95% CI) | 1.190 (1.080–1.311) | |||
No | No | Ref | Ref | |||||||||
No | Yes | 3.648 | 3.586–3.712 | 3.378 | 3.319–3.437 | 3.224 | 3.167–3.283 | RERI (95% CI) | 1.242 (0.972–1.509) | |||
Yes | No | 2.681 | 2.648–2.713 | 2.660 | 2.627–2.692 | 2.713 | 2.678–2.748 | AP (95% CI) | 0.201 (0.166–0.236) | |||
Yes | Yes | 6.783 | 6.513–7.064 | 6.236 | 5.985–6.497 | 6.179 | 5.922–6.447 | S (95% CI) | 1.315 (1.248–1.386) | |||
No | No | Ref | Ref | |||||||||
No | Yes | 2.773 | 2.575–2.987 | 3.378 | 3.319–3.437 | 2.704 | 2.506–2.918 | RERI (95% CI) | 0.708 (−0.121–1.537) | |||
Yes | No | 1.935 | 1.859–2.014 | 2.66 | 2.627–2.692 | 2.141 | 2.054–2.232 | AP (95% CI) | 0.155 (0.000–0.311) | |||
Yes | Yes | 3.956 | 3.323–4.708 | 6.236 | 5.985–6.497 | 4.554 | 3.816–5.433 | S (95% CI) | 1.249 (0.985–1.584) | |||
OR – odds ratio; CI – confidence interval; Ref – reference; GH – gestational hypertension; HPB – history of preterm birth; RERI – relative excess risk of interaction; AP – attributable proportion of interaction; S – synergy index. univariate analysis; the variables including age, race, and educational attainment of mother and father were corrected; adjusted variables included age, race, and educational attainment regarding father and mother, pre-pregnancy BMI, weight gain during pregnancy, cigarette smoking before and during pregnancy, method of delivery, number of fetus, payment source for delivery, previous cesarean, pre-pregnancy diabetes, gestational diabetes, infection, eclampsia, sex of infant. |