20 March 2022: Clinical Research
Aldosterone-to-Renin Ratio Is Associated with Diabetic Nephropathy in Type 2 Diabetic Patients: A Single-Center Retrospective Study
Mariko Higa 1ABCDEF* , Takamasa Ichijo 1AC , Takahisa Hirose 2EDOI: 10.12659/MSM.935615
Med Sci Monit 2022; 28:e935615
Table 1 Clinical characteristics of the patients studied.
| SEX (Male/Female) | 51/19 |
| Age (years) | 53.3±11.0 |
| BMI (kg/m) | 25.5±4.0 |
| Diabetic duration (years) | 7.1±6.1 |
| Diabetic treatment: Insulin/OHA/Diet alone | 36/29/5 |
| HbA1c (%) | 9.9±1.9 |
| Systolic BP (mmHg) | 115.3±24.1 |
| Diastolic BP (mmHg) | 75.0±12.2 |
| Hypertension (%) | 30 |
| Use of CCB (%) | 8.6 |
| LDL-cholesterol (mg/dl) | 118.2±37.1 |
| Triglyceride (mg/dl) | 219.8±352.0 |
| Serum creatinine (mg/dl) | 0.68±0.18 |
| eGFR (ml/min/1.73 m) | 86.9±21.8 |
| Albuminuria (mg/day) | 22.7±22.5 |
| PRA (ng/ml/hr) | 1.83±1.06 |
| Plasma aldpsterone (ng/dl) | 11.18±3.43 |
| ARR | 7.60±3.74 |
| OHA – oral hypoglycemic agents; BP – blood pressure; CCB – calcium channel blocker; eGFR – estimated glomerular filtration rate; PRA – plasma renin activity; ARR – aldosterone/renin ratio. Values are mean±SD. | |