09 May 2022>: Clinical Research
A Nomogram Model for Evaluating the Risk of Lymph Node Metastasis in cT2-cT4N0M0 Gastric Cancer Population
Zibo Zhang ABCDEF , Yu Liu AE* , Guohong Ma BE , Jixuan Su BDOI: 10.12659/MSM.935696
Med Sci Monit 2022; 28:e935696
Table 1 General information of patients in the 2 validation sets.
Variable | Internal validation set (n=236) | External validation set (n=100) | ||||||
---|---|---|---|---|---|---|---|---|
LNM(+) (n=108) | LNM(−) (n=128) | χ2 | P | LNM(+) (n=50) | LNM(−) (n=50) | χ2 | P | |
Age | 0.294 | 0.587 | 0.184 | 0.66 | ||||
36 | 47 | 15 | 17 | |||||
≥60 | 72 | 81 | 35 | 33 | ||||
Gender | 1.073 | 0.3 | 0.19 | 0.66 | ||||
Male | 79 | 101 | 34 | 36 | ||||
Female | 29 | 27 | 16 | 14 | ||||
Tumor site | 33.25 | 7.89 | 0.019 | |||||
Cardia and stomach fundus | 19 | 42 | 10 | 19 | ||||
Gastic body | 18 | 50 | 6 | 11 | ||||
Gastric antrum | 71 | 36 | 34 | 20 | ||||
Degree of differentiation | 38.54 | 16.64 | 0.002 | |||||
Poorly differentiated | 72 | 34 | 27 | 13 | ||||
Poorly to moderately differentiated | 15 | 33 | 13 | 12 | ||||
Moderately differentiated | 19 | 56 | 5 | 22 | ||||
Moderately to well-differentiated | 1 | 3 | 3 | 1 | ||||
Well-differentiated | 1 | 2 | 2 | 2 | ||||
Lauren type | 36.57 | 15.87 | ||||||
Intestinal type | 19 | 69 | 8 | 27 | ||||
Diffuse type | 37 | 34 | 15 | 8 | ||||
Mixed type | 52 | 25 | 27 | 15 | ||||
Depth of invation | 44.59 | 27.30 | ||||||
T2 | 28 | 89 | 9 | 34 | ||||
T3 | 4 | 2 | 2 | 1 | ||||
T4a | 69 | 34 | 34 | 12 | ||||
T4b | 7 | 3 | 5 | 3 | ||||
Presence of ulcers | 5.93 | 0.15 | 3.04 | 0.12 | ||||
Yes | 87 | 85 | 39 | 31 | ||||
No | 21 | 43 | 11 | 19 | ||||
Presence of vascular thrombi | 86.64 | 5.26 | 0.022 | |||||
Yes | 72 | 11 | 14 | 5 | ||||
No | 36 | 117 | 36 | 45 | ||||
Tumor size (cm) | 4.09±0.18 | 3.00±0.13 | – | 3.90±0.19 | 2.74±0.19 | – | ||
Ki67 (%) | 56.38±17.10 | 44.22±20.78 | – | 55.80±2.26 | 47.72±3.16 | – | 0.041 | |
CEA (ng/ml) | 9.44±3.88 | 3.74±0.68 | – | 0.15 | 3.42±0.62 | 4.80±1.61 | – | 0.98 |
CA19-9 (u/ml) | 24.28±4.49 | 14.30±2.52 | – | 0.045 | 19.07±5.33 | 18.97±5.35 | – | 0.42 |
CA72-4 (u/ml) | 10.21±3.57 | 4.79±0.91 | – | 0.12 | 5.27±2.10 | 5.95±1.62 | – | 0.79 |
AFP (ng/ml) | 10.22±3.57 | 3.61±0.52 | – | 0.07 | 4.14±0.49 | 3.18±0.19 | – | 0.077 |
LNM – lymph node metastasis; CEA – carcinoembryonic antigen; CA19-9 – carbohydrate antigen 19-9; CA72-4 – carbohydrate antigen 72-4; AFP – Alpha-fetoprotein. |