07 July 2022: Clinical Research
Optimal Timing and Outcomes of Minimally Invasive Approach in Acute Biliary Pancreatitis
Mihai Faur 12ABCE , Sorin Radu Fleaca 1CDFG , Claudia Diana Gherman 3ACF , Denisa Tanasescu 4BCEF , Ciprian Ionut Bacila 1CDFG , Dragos Serban 56CDF** , Laura Carina Tribus 78CDF , Corneliu Tudor 6DEF , Gabriel Catalin Smarandache 56CDF* , Daniel Ovidiu Costea 910CEF* , Mihail Silviu Tudosie 1112CEF , Dan Sabau 12ABCF , Gabriel Andrei Gangura 513DEF* , Ciprian Tanasescu 12ABCFDOI: 10.12659/MSM.937016
Med Sci Monit 2022; 28:e937016
Table 1 General data of patients included in the study.
| Parameter | Mild ABP (n=53) | Medium-severe ABP (n=24) | Severe ABP (n=57) | Total (n=143) | P value |
|---|---|---|---|---|---|
| Age (mean±SD, years) | 60.2±13.2 | 61.7±8.2 | 64.6±10.4 | 62.3±11.4 | 0.175* |
| Sex (female; male) | 13 (24.5%) | 11 (45.8%) | 30 (52.6%) | 54 (40.3%) | 0.008** |
| 40 (75.5%) | 13 (54.2%) | 27 (47.4%) | 80 (59.7%) | ||
| % Urban | 31 (58.5%) | 3 (12.5%) | 10 (17.5%) | 44 (32.8%) | ** |
| % Rural | 22 (41.5%) | 21 (87.5%) | 47 (82.5%) | 90 (67.2%) | |
| No. comorbidities | 0.9±0.8 | 1.6±1 | 2.4±1.3 | 1.69±1.3 | * |
| Comorbidities (no. patients, %) | |||||
| • Diabetes | 0 | 5 (20.8%) | 25 (43.9%) | 30 (22.4%) | ** |
| • Obesity | 0 | 0 | 20 (35.1%) | 20 (14.9%) | ** |
| • Chronic broncho pneumopathy | 0 | 2 (8.3%) | 25 (43.9%) | 27 (20.1%) | ** |
| • Arterial hypertension | 27 (50.9%) | 19 (62.5%) | 23 (40.4%) | 65 (48.5%) | 0.191** |
| • Ischemic coronary disease | 19 (35.8%) | 9 (37.5%) | 35 (61.4%) | 63 (47%) | 0.02** |
| Time from onset to hospitalization (days) | 1.8±1.1 | 2.6±0.4 | 5.6±1.1 | 3.5±2 | * |
| Amylase (mean±SD, UI/L) | 232.40±43.9 | 404.8±52.3 | 2067.8±777.9 | 1044±1020 | * |
| Bilirubin (mean±SD, mg/dL) | 2±0.7 | 3.4±0.5 | 15.1±5 | 7.8±7.1 | * |
| ALT (mean±SD, UI/L) | 75.4±18.4 | 275.5±41.6 | 681±110.8 | 368.9±288.5 | * |
| AST (mean±SD, UI/L) | 88.7±21.2 | 323±50.2 | 646.4±138.6 | 367.9±270.8 | * |
| Leukocytes (mean±SD, nr/mmc) | 12706±941.3 | 15422.5±779 | 22370.7±3947.7 | 17312.7±5200.4 | * |
| Leukocytes >15 000/mmc | 0 | 18 (75%) | 57 (100%) | 75 (52.4%) | ** |
| NLR (mean±SD) | 8.6±2.4 | 11.6±1.9 | 19.8±2.8 | 13.9±5.7 | * |
| Creatinine (mean±SD) | 0.7±0.5 | 3.3±1 | 7.6±1.6 | 4.1±3.3 | * |
| Creatinine >2 (no. of patients,%) | 0 | 20 (83.3%) | 56 (98.2%) | 76 (53.1%) | ** |
| Balthasar CT score at admission: | |||||
| A | 18 (34%) | 0 | 0 | 18 (13.4%) | ** |
| B | 33 (62%) | 2 (8%) | 0 | 35 (26.1%) | |
| C | 2 (4%) | 21 (88%) | 1 (2%) | 24 (17.9%) | |
| D | 0 | 1 (4%) | 50 (87.5%) | 51 (38.1%) | |
| E | 0 | 0 | 6 (10.5%) | 6 (4.5%) | |
| * Kruskal-Wallis Test; ** Fisher exact test. ABP – acute biliary pancreatitis; ALT – alanine aminotransferase; AST – aspartate aminotransferase; CT – computed tomography; NLR – neutrophil-to-lymphocyte ratio; SD – standard deviation. | |||||