29 November 2022: Clinical Research
Sex-Related Differences in Sitagliptin Treatment in Type 2 Diabetes: Results from the PROLOGUE Trial
Xilin Wu 1ABCDEF , Shiming Zhang 1ABCEF , Yingzhu Jin 2ABC , Xun Xiao 3ABCDEF*DOI: 10.12659/MSM.938030
Med Sci Monit 2022; 28:e938030
Table 4 Comparison of atherosclerotic parameters at baseline, 12 months, and 24 months in female participants.
| Variables | Time point | Sitagliptin group | Conventional group | P-value |
|---|---|---|---|---|
| N | 76 | 69 | ||
| Mean IMT in the right CCA, mm | At baseline | 0.83±0.16 | 0.79±0.15 | 0.115 |
| Mean IMT in the left CCA, mm | At baseline | 0.83±0.20 | 0.81±0.21 | 0.624 |
| Mean IMT in the right CCA, mm | 12 months | 0.81±0.17 | 0.79±0.15 | 0.624 |
| Mean IMT in the left CCA, mm | 12 months | 0.80±0.15 | 0.82±0.16 | 0.549 |
| Mean IMT in the right CCA, mm | 24 months | 0.82±0.19 | 0.81±0.18 | 0.748 |
| Mean IMT in the left CCA, mm | 24 months | 0.81±0.17 | 0.82±0.20 | 0.954 |
| Mean IMT in the right bulb, mm | At baseline | 1.14±0.66 | 1.09±0.41 | 0.621 |
| Mean IMT in the left bulb, mm | At baseline | 1.13±0.53 | 1.04±0.49 | 0.340 |
| Mean IMT in the right bulb, mm | 12 months | 1.01±0.47 | 1.23±0.51 | 0.049 |
| Mean IMT in the left bulb, mm | 12 months | 1.24±0.75 | 1.19±0.59 | 0.750 |
| Mean IMT in the right bulb, mm | 24 months | 1.14±0.61 | 1.17±0.48 | 0.776 |
| Mean IMT in the left bulb, mm | 24 months | 1.16±0.64 | 1.24±0.72 | 0.592 |
| Mean IMT in the right ICA, mm | At baseline | 0.69±0.28 | 0.73±0.30 | 0.459 |
| Mean IMT in the left ICA, mm | At baseline | 0.69±0.18 | 0.75±0.42 | 0.367 |
| Mean IMT in the right ICA, mm | 12 months | 0.80±0.35 | 0.83±0.49 | 0.797 |
| Mean IMT in the left ICA, mm | 12 months | 0.90±0.46 | 0.83±0.42 | 0.497 |
| Mean IMT in the right ICA, mm | 24 months | 0.70±0.30 | 0.80±0.57 | 0.323 |
| Mean IMT in the left ICA, mm | 24 months | 0.69±0.29 | 0.80±0.42 | 0.169 |
| Max IMT in the right CCA, mm | At baseline | 1.06±0.21 | 1.01±0.20 | 0.129 |
| Max IMT in the left CCA, mm | At baseline | 1.05±0.35 | 1.04±0.26 | 0.806 |
| Max IMT in the right CCA, mm | 12 months | 1.01±0.22 | 1.00±0.22 | 0.811 |
| Max IMT in the left CCA, mm | 12 months | 1.02±0.24 | 1.03±0.22 | 0.926 |
| Max IMT in the right CCA, mm | 24 months | 1.06±0.29 | 1.02±0.23 | 0.524 |
| Max IMT in the left CCA, mm | 24 months | 1.04±0.25 | 1.04±0.27 | 0.989 |
| Max IMT in the right bulb, mm | At baseline | 1.62±1.01 | 1.60±0.65 | 0.864 |
| Max IMT in the left bulb, mm | At baseline | 1.62±0.80 | 1.49±0.80 | 0.367 |
| Max IMT in the right bulb, mm | 12 months | 1.39±0.65 | 1.71±0.77 | 0.042 |
| Max IMT in the left bulb, mm | 12 months | 1.61±0.94 | 1.66±0.83 | 0.802 |
| Max IMT in the right bulb, mm | 24 months | 1.63±0.88 | 1.71±0.70 | 0.628 |
| Max IMT in the left bulb, mm | 24 months | 1.59±0.81 | 1.71±0.96 | 0.515 |
| Max IMT in the right ICA, mm | At baseline | 0.93±0.40 | 1.00±0.44 | 0.374 |
| Max IMT in the left ICA, mm | At baseline | 0.92±0.28 | 0.98±0.53 | 0.485 |
| Max IMT in the right ICA, mm | 12 months | 1.05±0.44 | 1.10±0.58 | 0.685 |
| Max IMT in the left ICA, mm | 12 months | 1.20±0.59 | 1.09±0.50 | 0.357 |
| Max IMT in the right ICA, mm | 24 months | 0.94±0.35 | 1.06±0.72 | 0.328 |
| Max IMT in the left ICA, mm | 24 months | 0.97±0.49 | 1.08±0.57 | 0.360 |
| Plaque area, mm2 | At baseline | 11.17±9.44 | 9.24±4.31 | 0.212 |
| Plaque gray scale median | At baseline | 52.79±28.26 | 51.81±17.33 | 0.842 |
| Plaque area, mm | 12 months | 12.66±9.34 | 11.73±4.07 | 0.668 |
| Plaque area, mm | 24 months | 10.86±6.81 | 10.30±4.05 | 0.668 |
| Plaque gray scale median | 12 months | 54.77±40.66 | 75.57±53.51 | 0.203 |
| Plaque gray scale median | 24 months | 43.92±19.10 | 51.81±19.85 | 0.096 |