28 March 2024: Clinical Research
Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Predicting Complete Pathological Response in Rectal Cancer Patients Receiving Neoadjuvant Chemoradiotherapy
Mustafa Karaca 1ACDEF* , Ece Salim 2ABDEF , Mustafa Serkan Alemdar 3BDEF , Özge Deniz Karaca 2BEF , Mustafa Özgür Arıcı 3BDEFDOI: 10.12659/MSM.943750
Med Sci Monit 2024; 30:e943750
Table 3 Patient characteristics according to NLR groups.
| Variables | NLR <3.63 (n=137) | NLR >3.63 (n=50) | p |
|---|---|---|---|
| Age (years), mean±SD | 63.47±11.6 | 67.64±9.44 | |
| Gender, n (%) | |||
| Male | 82 (59.9) | 41 (82) | |
| Female | 55 (40.1) | 9 (18) | |
| Comorbid disease, n (%) | 57 (41.6) | 18 (36) | 0.489 |
| Diabetes mellitus | 28 (20.4) | 9 (18) | 0.711 |
| Hypertension | 2 (1.5) | 0 (0) | 0.999 |
| Ulcerative colitis | 26 (19) | 8 (16) | 0.640 |
| Coronary artery disease | 1 (0.7) | 1 (2) | 0.464 |
| Chemotherapy agent, n (%) | |||
| Capecitabine | 82 (59.9) | 14 (28) | |
| 5-FU | 55 (40.1) | 36 (72) | |
| Type of surgery, n (%) | |||
| LAR | 111 (81) | 43 (86) | 0.429 |
| MILES operation | 26 (19) | 7 (14) | |
| Pathological response, n (%) | |||
| Complete response | 25 (18.2) | 9 (18) | |
| Near complete response | 52 (38) | 9 (18) | |
| Partial response | 46 (33.6) | 22 (44) | |
| No response | 14 (10.2) | 10 (20) | |
| Poor response, n (%) | 60 (43.8) | 32 (64) | |
| Hemoglobin at diagnosis, mean±SD | 12.61±2.03 | 12.11±2.14 | 0.145 |
| Platelets at diagnosis, median (IQR) | 276 (239–341) | 288 (220–333) | 0.328 |
| LDH at diagnosis, median (IQR) | 191 (165–228) | 191.5 (163–222) | 0.480 |
| Independent t-test, Mann-Whitney U test, Pearson chi-square test, Fisher’s Exact test. NLR – Neutrophil/lymphocyte ratio; 5-FU – 5-Fluorouracil; LAR – low anterior resection; LDH – lactate dehydrogenase. The same lowercase letters in a row indicate that there is no significant difference between the groups. | |||